Activity log

Paper and Magazine


LIME multi center study

Special collection from the Lid and Meibomian Gland Working Group.

Arita R
Ocul Surf. 2020 Jan 24. pii: S1542-0124(20)30017-3.

Non-pharmaceutical treatment options for meibomian gland dysfunction.

Arita R, Fukuoka S.
Clin Exp Optom. 2020 Jan 13.

Meibomian Gland Dysfunction and Dry Eye are Similar, but Different based on a Population-Based Study (Hirado-Takushima Study) in Japan.

Arita R, Mizoguchi T, Kawashima M, Fukuoka S, Koh S, Shirakawa R,
Suzuki T, Morishige N.
Am J Ophthalmol. 2019 Mar 6. pii: S0002-9394(19)30083-2.

Therapeutic Efficacy of Intense Pulsed Light in Patients with Refractory Meibomian Gland Dysfunction

Reiko Arita, MD, PhD, Shima Fukuoka, MD, Naoyuki Morishige, MD,PhD
(LIME working group)
Ocular Surface in press

Clinical Impression of the Efficacy of Eyelid Warming or Lid Hygiene as Treatment for Meibomian Gland Dysfunction

Arita R, Kawashima M, Morishige N.(LIME working group)
Journal of Clinical & Experimental Ophthalmology in press

Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction

Arita R, Mizoguchi T, Fukuoka S, Morishige N. (LIME working group)
CORNEA in press

Functional Morphology of the Lipid Layer of the Tear Film.

Arita R, Fukuoka S, Morishige N.
Cornea. 2017 Nov;36 Suppl 1:S60-S66.

New insights into the morphology and function of meibomian glands.

Arita R, Fukuoka S, Morishige N.
Exp Eye Res. 2017 Oct;163:64-71.

Meibomian Gland Dysfunction and Contact Lens Discomfort.

Arita R, Fukuoka S, Morishige N.
Eye Contact Lens. 2017 Jan;43(1):17-22.

Morphology and Function of Meibomian Glands and Other Tear Film Parameters in Junior High School Students.

Mizoguchi T, Arita R, Fukuoka S, Morishige N.
Cornea. 2017 Aug;36(8):922-926.

Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion.

Fukuoka S, Arita R, Shirakawa R, Morishige N.
Clin Ophthalmol. 2017 May 30;11:1031-1038.

Clinical safety and efficacy of vitamin D3 analog ointment for treatment of obstructive meibomian gland dysfunction.

Arita R, Kawashima M, Ito M, Tsubota K.
BMC Ophthalmol. 2017 Jun 7;17(1):84.

New Insights Into the Lipid Layer of the Tear Film and Meibomian Glands.

Arita R, Fukuoka S, Morishige N.
Eye Contact Lens. 2017 Nov;43(6):335-339.

Increase in tear film lipid layer thickness after instillation of 3% diquafosol ophthalmic solution in healthy human eyes.

Fukuoka S, Arita R.
Ocul Surf. 2017 Oct;15(4):730-735.

Effects of a warm compress containing menthol on the tear film in healthy subjects and dry eye patients.

Arita R, Morishige N, Sakamoto I, Imai N, Shimada Y, Igaki M, Suzuki A,
Itoh K, Tsubota K.
Sci Rep. 2017 Apr 5;7:45848.

Development of Definitive and Reliable Grading Scales for Meibomian Gland Dysfunction.

Arita R, Minoura I, Morishige N, Shirakawa R, Fukuoka S, Asai K, Goto T, Imanaka T, Nakamura M.
Am J Ophthalmol. 2016 Sep;169:125-37.

Tear Interferometric Patterns Reflect Clinical Tear Dynamics in Dry Eye Patients.

Arita R, Morishige N, Fujii T, Fukuoka S, Chung JL, Seo KY, Itoh K.
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3928-34.

Morphological changes in the meibomian glands of patients with phlyctenular keratitis: a multicenter cross-sectional study.

Suzuki T, Morishige N, Arita R, Koh S, Sakimoto T, Shirakawa R, Miyata K, Ohashi Y.
BMC Ophthalmol. 2016 Oct 10;16(1):178.

Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction.

Arita R, Morishige N, Shirakawa R, Sato Y, Amano S.
Ocul Surf. 2015 Oct;13(4):321-30.

Increased Tear Fluid Production as a Compensatory Response to Meibomian Gland Loss: A Multicenter Cross-sectional Study.

Arita R, Morishige N, Koh S, Shirakawa R, Kawashima M, Sakimoto T, Suzuki T, Tsubota K.
Ophthalmology. 2015 May;122(5):925-33.

Papers regarding Meibomian gland related diseases by LIME members

Efficacy of Plate Expression of Meibum on Tear Function and Ocular Surface Findings in Meibomian Gland Disease.

Aketa N, Shinzawa M, Kawashima M, Dogru M, Okamoto S, Tsubota K, Shimazaki J.
Eye Contact Lens. 2018 Sep 21. [Epub ahead of print]

Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye.

Vu CHV, Kawashima M, Yamada M, Suwaki K, Uchino M, Shigeyasu C, Hiratsuka Y, Yokoi N, Tsubota K; Dry Eye Cross-Sectional Study in Japan Study Group.
Ophthalmology. 2018 Aug;125(8):1181-1188.

The effects of 3% diquafosol sodium eye drop application on meibomian gland and ocular surface alterations in the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice.

Ikeda K, Simsek C, Kojima T, Higa K, Kawashima M, Dogru M, Shimizu T, Tsubota K, Shimazaki J.
Graefes Arch Clin Exp Ophthalmol. 2018 Apr;256(4):739-750.

Eyelid cleansing with ointment for obstructive meibomian gland dysfunction.

Kaido M, Ibrahim OM, Kawashima M, Ishida R, Sato EA, Tsubota K.
Jpn J Ophthalmol. 2017 Jan;61(1):124-130.

Regional Differences in Tear Film Stability and Meibomian Glands in Patients With Aqueous-Deficient Dry Eye.

Koh S, Ikeda C, Fujimoto H, Oie Y, Soma T, Maeda N, Nishida K.
Eye Contact Lens. 2016 Jul;42(4):250-5.

Analysis of Meibum Before and After Intraductal Meibomian Gland Probing in Eyes With Obstructive Meibomian Gland Dysfunction.

Nakayama N, Kawashima M, Kaido M, Arita R, Tsubota K.
Cornea. 2015 Oct;34(10):1206-8.

Meibum Color and Free Fatty Acid Composition in Patients With Meibomian Gland Dysfunction.

Arita R, Mori N, Shirakawa R, Asai K, Imanaka T, Fukano Y, Nakamura M, Amano S.
Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4403-12.

New Eye Cleansing Product Improves Makeup-Related Ocular Problems.

Okura M, Kawashima M, Katagiri M, Shirasawa T, Tsubota K.
J Ophthalmol. 2015;2015:831628

Tear lipid layer deficiency associated with incomplete blinking: a case report.

Kawashima M, Tsubota K.
BMC Ophthalmol. 2013 Jul 16;13:34.

Application by non-invasive meibography other than dry eye

Granular corneal dystrophy type 2 is associated with morphological abnormalities of meibomian glands.

Sakimoto T.
Br J Ophthalmol. 2015 Jan;99(1):26-8.

Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography.

Nemoto Y, Arita R, Mizota A, Sasajima Y.
Clin Ophthalmol. 2014 Sep 18;8:1869-75.

Peters’ anomaly imaged with an infrared anterior segment camera.

Morishige N, Yamada N, Morita Y, Sonoda KH.
Clin Exp Ophthalmol. 2014 May-Jun;42(4):391-2.

Visualization of the meibomian glands by means of noncontact mobile-type meibography (Meibopen) in a 16-year-old girl with unilateral marginal staphylococcal keratitis.

Koh S, Maeda N, Nishida K.
J AAPOS. 2014 Feb;18(1):99-101.


Nippon ganka gakkai zasshi 118, 6: 523

Tuesday, May 5, 2013Tokyo,Japan

Effects of eyelid warming devices on tear film parameters in normal subjects and patients with meibomian gland dysfunction

Reiko Arita1,4, Naoyuki Morishige4,5, Rika Shirakawa2,4, Youichi Sato5, Shiro Amano2

  • 1)Department of Ophthalmology, Itoh Clinic
  • 2)Department of Ophthalmology, University of Tokyo School of Medicine
  • 3)Department of Ophthalmology, Keio University School of Medicine
  • 4)LIME Working Group
  • 5)Department of Ophthalmology, Yamaguchi University, Graduate School of Medicine