LIME 多施設 study

Therapeutic Efficacy and Safety of Intense Pulsed Light for Refractive Multiple Recurrent Chalazia.

Arita R, Fukuoka S
J Clin Med. 2022 Sep 11;11(18):5338. doi: 10.3390/jcm11185338.PMID: 36142985

Comparison of Intense Pulsed Light Therapy on Patients with Meibomian Gland Dysfunction Using AQUA CEL and M22 Devices.

Fukuoka S, Arita R.
J Clin Med. 2022 Jul 22;11(15):4265. doi: 10.3390/jcm11154265.

Exploratory Search for Characteristic Symptoms to Distinguish Meibomian Gland Dysfunction from Dry Eye in a Population-Based Study in Japan.

Arita R, Mizoguchi T, Kawashima M, Fukuoka S, Koh S, Shirakawa R, Suzuki T, Morishige N.
J Clin Med. 2022 Mar 19;11(6):1715. doi: 10.3390/jcm11061715.PMID: 35330039 Free PMC article.

Relation of Dietary Fatty Acids and Vitamin D to the Prevalence of Meibomian Gland Dysfunction in Japanese Adults: The Hirado-Takushima Study.

Fukuoka S, Arita R, Mizoguchi T, Kawashima M, Koh S, Shirakawa R, Suzuki T, Sasaki S, Morishige N.
J Clin Med. 2021 Jan 18;10(2):350. doi:10.3390/jcm10020350.

Proposed Algorithm for Management of Meibomian Gland Dysfunction Based on Noninvasive Meibography.

Arita R, Fukuoka S, Kawashima M.
J Clin Med.2020 Dec 27;10(1):65. doi:10.3390/jcm10010065.
PMID: 33375436 Free PMC article.

Assessment of meibomian gland morphology by noncontact infrared meibography in Shih Tzu dogs with or without keratoconjunctivitis sicca.

Kitamura Y, Maehara S, Nakade T, Miwa Y, Arita R, Iwashita H, Saito A.
Vet Ophthalmol. 2019 Nov;22(6):744-750.

Intense pulsed light treatment in meibomian gland dysfunction: A concise review.

Tashbayev B, Yazdani M, Arita R, Fineide F, Utheim TP.
Ocul Surf. 2020 Jul 3;18(4):583-594.

Efficacy of Azithromycin Eyedrops for Individuals With Meibomian Gland Dysfunction-Associated Posterior Blepharitis.

Arita R, Fukuoka S.
Eye Contact Lens. 2020 Jul 7.

Histopathologic changes associated with Meibomian Gland dropout in a dog.

Kitamura Y, Arita R, Miwa Y, Iwashita H, Saito A.
Vet Ophthalmol. 2020 May;23(3):575-578.

Multicenter Study of Intense Pulsed Light for Patients with Refractory Aqueous-Deficient Dry Eye Accompanied by Mild Meibomian Gland Dysfunction

Arita R, Fukuoka S, Mizoguchi T and Morishige N
J Clin Med. 2020 Oct 28;9(11):3467.doi: 10.3390/jcm9113467.

Special collection from the Lid and Meibomian Gland Working Group.

Arita R
Ocul Surf. 2020 Jan 24. pii: S1542-0124(20)30017-3.

Non-pharmaceutical treatment options for meibomian gland dysfunction.

Arita R, Fukuoka S.
Clin Exp Optom. 2020 Jan 13.

Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction: a randomized clinical study

Shima Fukuoka, Reiko Arita
Sci Rep. 2019 Jun 24;9(1):9091.

Automated Measurement of Tear Meniscus Height with the Kowa DR-1α Tear Interferometer in Both Healthy Subjects and Dry Eye Patients

Reiko Arita, Katsumi Yabusaki, Taisuke Hirono, Takanori Yamauchi,
Tadashi Ichihashi, Shima Fukuoka, Naoyuki Morishige
Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2092-2101.

Meibomian Gland Dysfunction and Dry Eye are Similar, but Different based on a Population-Based Study (Hirado-Takushima Study) in Japan.

Arita R, Mizoguchi T, Kawashima M, Fukuoka S, Koh S, Shirakawa R, Suzuki T, Morishige N.
Am J Ophthalmol. 2019 Mar 6. pii: S0002-9394(19)30083-2.

Therapeutic Efficacy of Intense Pulsed Light in Patients with Refractory Meibomian Gland Dysfunction

Reiko Arita, MD, PhD, Shima Fukuoka, MD, Naoyuki Morishige, MD,PhD
(LIME working group)
Ocul Surf. 2019 Jan;17(1):104-110.doi: 10.1016/j.jtos.2018.11.004.

Clinical Impression of the Efficacy of Eyelid Warming or Lid Hygiene as Treatment for Meibomian Gland Dysfunction

Arita R, Kawashima M, Morishige N.
January 2018Journal of Clinical and Experimental Ophthalmology 09(05)

Multicenter Study of Intense Pulsed Light Therapy for Patients With Refractory Meibomian Gland Dysfunction

Arita R, Mizoguchi T, Fukuoka S, Morishige N.
Cornea.2018 Dec;37(12):1566-1571. doi: 10.1097/ICO.0000000000001687.

Functional Morphology of the Lipid Layer of the Tear Film.

Arita R, Fukuoka S, Morishige N.
Cornea. 2017 Nov;36 Suppl 1:S60-S66.

New insights into the morphology and function of meibomian glands.

Arita R, Fukuoka S, Morishige N.
Exp Eye Res. 2017 Oct;163:64-71.

Meibomian Gland Dysfunction and Contact Lens Discomfort.

Arita R, Fukuoka S, Morishige N.
Eye Contact Lens. 2017 Jan;43(1):17-22.

Morphology and Function of Meibomian Glands and Other Tear Film Parameters in Junior High School Students.

Mizoguchi T, Arita R, Fukuoka S, Morishige N.
Cornea. 2017 Aug;36(8):922-926.

Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion.

Fukuoka S, Arita R, Shirakawa R, Morishige N.
Clin Ophthalmol. 2017 May 30;11:1031-1038.

Clinical safety and efficacy of vitamin D3 analog ointment for treatment of obstructive meibomian gland dysfunction.

Arita R, Kawashima M, Ito M, Tsubota K.
BMC Ophthalmol. 2017 Jun 7;17(1):84.

New Insights Into the Lipid Layer of the Tear Film and Meibomian Glands.

Arita R, Fukuoka S, Morishige N.
Eye Contact Lens. 2017 Nov;43(6):335-339.

Increase in tear film lipid layer thickness after instillation of 3% diquafosol ophthalmic solution in healthy human eyes.

Fukuoka S, Arita R.
Ocul Surf. 2017 Oct;15(4):730-735.

Effects of a warm compress containing menthol on the tear film in healthy subjects and dry eye patients.

Arita R, Morishige N, Sakamoto I, Imai N, Shimada Y, Igaki M, Suzuki A,
Itoh K, Tsubota K.
Sci Rep. 2017 Apr 5;7:45848.

Development of Definitive and Reliable Grading Scales for Meibomian Gland Dysfunction.

Arita R, Minoura I, Morishige N, Shirakawa R, Fukuoka S, Asai K, Goto T, Imanaka T, Nakamura M.
Am J Ophthalmol. 2016 Sep;169:125-37.

Tear Interferometric Patterns Reflect Clinical Tear Dynamics in Dry Eye Patients.

Arita R, Morishige N, Fujii T, Fukuoka S, Chung JL, Seo KY, Itoh K.
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3928-34.

Morphological changes in the meibomian glands of patients with phlyctenular keratitis: a multicenter cross-sectional study.

Suzuki T, Morishige N, Arita R, Koh S, Sakimoto T, Shirakawa R, Miyata K, Ohashi Y.
BMC Ophthalmol. 2016 Oct 10;16(1):178.

Effects of Eyelid Warming Devices on Tear Film Parameters in Normal Subjects and Patients with Meibomian Gland Dysfunction.

Arita R, Morishige N, Shirakawa R, Sato Y, Amano S.
Ocul Surf. 2015 Oct;13(4):321-30.

Increased Tear Fluid Production as a Compensatory Response to Meibomian Gland Loss: A Multicenter Cross-sectional Study.

Arita R, Morishige N, Koh S, Shirakawa R, Kawashima M, Sakimoto T,
Suzuki T, Tsubota K.
Ophthalmology. 2015 May;122(5):925-33.


Demodex-Mite Infestation in Cilia and its Association With Ocular Surface Parameters in Japanese Volunteers.

Mizuno M, Kawashima M, Uchino M, Suzuki N, Mitamura H, Uchino Y, Yokoi N, Tsubota K
Eye Contact Lens. 2020 Sep;46(5):291-296.
doi: 10.1097/ICL.0000000000000656. PMID: 31517735

Investigation of Meibomian Gland Function and Dry Eye Disease in Patients with Graves’ Ophthalmopathy.

Inoue S, Kawashima M, Arita R, Kozaki A, Tsubota K.
J Clin Med. 2020 Aug 31;9(9):E2814. doi: 10.3390/jcm9092814.
PMID: 32878140

Morphological Changes of Meibomian Glands in Men With Benign Prostate Hyperplasia.

Shimizu S, Arita R, Kawashima M, Inoue S, Itoh K, Tsubota K.
Cornea. 2020 Aug 19. doi: 10.1097/ICO.0000000000002454.
Online ahead of print. PMID: 32826647

Advances in the diagnosis and treatment of dry eye.

Kojima T, Dogru M, Kawashima M, Nakamura S, Tsubota K.
Prog Retin Eye Res. 2020 Jan 29:100842.
doi: 10.1016/j.preteyeres.2020.100842. Online ahead of print.
PMID: 32004729 Review.

Efficacy of Plate Expression of Meibum on Tear Function and Ocular Surface Findings in Meibomian Gland Disease.

Aketa N, Shinzawa M, Kawashima M, Dogru M, Okamoto S, Tsubota K, Shimazaki J.
Eye Contact Lens. 2019 Jan;45(1):19-22.

Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye.

Vu CHV, Kawashima M, Yamada M, Suwaki K, Uchino M, Shigeyasu C, Hiratsuka Y, Yokoi N, Tsubota K; Dry Eye Cross-Sectional Study in Japan Study Group.
Ophthalmology. 2018 Aug;125(8):1181-1188.

The effects of 3% diquafosol sodium eye drop application on meibomian gland and ocular surface alterations in the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice.

Ikeda K, Simsek C, Kojima T, Higa K, Kawashima M, Dogru M, Shimizu T, Tsubota K, Shimazaki J.
Graefes Arch Clin Exp Ophthalmol. 2018 Apr;256(4):739-750.

Eyelid cleansing with ointment for obstructive meibomian gland dysfunction.

Kaido M, Ibrahim OM, Kawashima M, Ishida R, Sato EA, Tsubota K.
Jpn J Ophthalmol. 2017 Jan;61(1):124-130.

Regional Differences in Tear Film Stability and Meibomian Glands in Patients With Aqueous-Deficient Dry Eye.

Koh S, Ikeda C, Fujimoto H, Oie Y, Soma T, Maeda N, Nishida K.
Eye Contact Lens. 2016 Jul;42(4):250-5.

Analysis of Meibum Before and After Intraductal Meibomian Gland Probing in Eyes With Obstructive Meibomian Gland Dysfunction.

Nakayama N, Kawashima M, Kaido M, Arita R, Tsubota K.
Cornea. 2015 Oct;34(10):1206-8.

Meibum Color and Free Fatty Acid Composition in Patients With Meibomian Gland Dysfunction.

Arita R, Mori N, Shirakawa R, Asai K, Imanaka T, Fukano Y, Nakamura M, Amano S.
Invest Ophthalmol Vis Sci. 2015 Jul;56(8):4403-12.

New Eye Cleansing Product Improves Makeup-Related Ocular Problems.

Okura M, Kawashima M, Katagiri M, Shirasawa T, Tsubota K.
J Ophthalmol. 2015;2015:831628

Tear lipid layer deficiency associated with incomplete blinking: a case report.

Kawashima M, Tsubota K.
BMC Ophthalmol. 2013 Jul 16;13:34.

LIME International Member との共同研究

Topical glaucoma medications – Clinical implications for the ocular surface.

Fineide F, Lagali N, Adil MY, Arita R, Kolko M, Vehof J, Utheim TP.
Ocul Surf. 2022 Jul 31;26:19-49. doi: 10.1016/j.jtos.2022.07.007. Online ahead of print.PMID: 35921942 Free article. Review.

Association of Serum Lipid Level with Meibum Biosynthesis and Meibomian Gland Dysfunction: A Review.

Yoo YS, Park SK, Hwang HS, Kim HS, Arita R, Na KS.
J Clin Med. 2022 Jul 11;11(14):4010. doi: 10.3390/jcm11144010.PMID: 35887773 Free PMC article. Review.

Intraductal meibomian gland probing and its efficacy in the treatment of meibomian gland dysfunction.

Magno M, Moschowits E, Arita R, Vehof J, Utheim TP.
Surv Ophthalmol. 2021 Jul-Aug;66(4):612-622. Review.

Relationship between serum lipid level and meibomian gland dysfunction subtype in Korea using propensity score matching.

Ha M, Song J, Park S, Han K, Hwang HS, Kim HS, Arita R, Na KS.
Sci Rep. 2021 Aug 9;11(1):16102. doi: 10.1038/s41598-021-95599-y.

Effects of Lipiflow Treatment Prior to Cataract Surgery: A Prospective, Randomized, Controlled Study.

Park J, Yoo YS, Shin K, Han G, Arita R, Lim DH, Chung TY.
Am J Ophthalmol. 2021 Oct;230:264-275. doi: 10.1016/j.ajo.2021.04.031. Epub 2021 May 13.PMID: 33992615 Clinical Trial.

The role of meibography in ocular surface diagnostics: A review.

Fineide F, Arita R, Utheim TP.
Ocul Surf. 2021 Jan;19:133-144. Review.


Granular corneal dystrophy type 2 is associated with morphological abnormalities of meibomian glands.

Sakimoto T.
Br J Ophthalmol. 2015 Jan;99(1):26-8.

Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography.

Nemoto Y, Arita R, Mizota A, Sasajima Y.
Clin Ophthalmol. 2014 Sep 18;8:1869-75.

Peters’ anomaly imaged with an infrared anterior segment camera.

Morishige N, Yamada N, Morita Y, Sonoda KH.
Clin Exp Ophthalmol. 2014 May-Jun;42(4):391-2.

Visualization of the meibomian glands by means of noncontact mobile-type meibography (Meibopen) in a 16-year-old girl with unilateral marginal staphylococcal keratitis.

Koh S, Maeda N, Nishida K.
J AAPOS. 2014 Feb;18(1):99-101.


あたらしい眼科 37巻04号 p.104-(2020.04)

清水 翔太, 有田 玲子, 井上 佐智子, 伊藤 耕三, 川島 素子, 坪田 一男

日本眼科学会雑誌118巻 第6号523


  • 1)伊藤医院
  • 2)東京大
  • 3)慶應大
  • 4)LIME研究会
  • 5)山口大

Frontiers in Dry Eye「涙液から見たオキュラーサーフェス 」12巻1号p.8-17(2017.04)

島崎 潤, 天野 史郎, 鈴木 智, 川島 素子

FRAGRANCE JOURNAL 44巻7号 p.27-32(2016.07)

井上 佐智子, 川島 素子

あたらしい眼科 30巻11号 p.1573-1574(2013.11)

新しい治療と検査シリーズ アイシャンプー(解説)
川島 素子

Frontiers in Dry Eye「涙液から見たオキュラーサーフェス 」7巻1号p.56-61(2012.04)

ドライアイ基本講座 基本手技シリーズ リッドハイジーン
川島 素子