LIME研究会

活動記録

論文掲載

LIME 多施設 study

Meibomian Gland Dysfunction and Contact Lens Discomfort.

Reiko Arita,1,2, Shima Fukuoka,2,3, Naoyuki Morishige,2,4

  • 1)Department of Ophthalmology, Itoh Clinic
  • 2)Lid and Meibomian Gland Working Group (LIME)
  • 3)Department of Ophthalmology, Omiya Hamada Eye Clinic
  • 4)Department of Ophthalmology, Oshima Eye Hospital
<abstract>

Morphology and Function of Meibomian Glands and Other Tear Film Parameters in Junior High School Students.

Mizoguchi Takanori,1,2, Reiko Arita,2,3, Shima Fukuoka,2,4,
Naoyuki Morishige,2,5

  • 1)Mizoguchi Eye Clinic
  • 2)Lid and Meibomian Gland Working Group (LIME)
  • 3)Department of Ophthalmology, Itoh Clinic
  • 4)Department of Ophthalmology, Omiya Hamada Eye Clinic
  • 5)Department of Ophthalmology, Oshima Eye Hospital
<abstract>

Changes in meibomian gland morphology and ocular higher-order aberrations in eyes with chalazion.

Shima Fukuoka,1,2,3, Reiko Arita,2,3,4, Rika Shirakawa,2,3,
Naoyuki Morishige,2,5

  • 1)Department of Ophthalmology, Omiya Hamada Eye Clinic
  • 2)Lid and Meibomian Gland Working Group (LIME)
  • 3)Department of Ophthalmology, University of Tokyo School of Medicine
  • 4)Department of Ophthalmology, Itoh Clinic
  • 5)Department of Ophthalmology, Oshima Eye Hospital
<abstract>

Clinical safety and efficacy of vitamin D3 analog ointment for treatment of obstructive meibomian gland dysfunction.

Reiko Arita,1,2, Motoko Kawashima,2, Masataka Ito,3, Kazuo Tsubota,2

  • 1)Department of Ophthalmology, Itoh Clinic, Saitama, Japan
  • 2)Department of Ophthalmology, Keio University, Tokyo, Japan
  • 3)3Department of Developmental Anatomy and Regenerative Biology, National Defense Medical College, Saitama, Japan
<abstract>

New Insights Into the Lipid Layer of the Tear Film and Meibomian Glands.

Reiko Arita,1,4, Shima Fukuoka,2,4, Naoyuki Morishige,3,4

  • 1)Department of Ophthalmology, Itoh Clinic, Saitama, Japan
  • 2)Omiya Hamada Eye Clinic, Saitama, Japan
  • 3)Oshima Ophthalmology Hospital, Fukuoka, Japan
  • 4)Lid and Meibomian Gland Working Group (LIME)
<abstract>

Increase in Tear Film Lipid Layer Thickness after Instillation of 3% Diquafosol Ophthalmic Solution in Healthy Human Eyes

Shima Fukuoka, MD1,2,3, Reiko Arita, MD, PhD2,3,4

  • 1)Omiya Hamada Eye Clinic, Saitama, Japan
  • 2)Lid and Meibomian Gland Working Group (LIME)
  • 3)Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  • 4)Department of Ophthalmology, Itoh Clinic, Saitama, Japan

Effects of a warm compress containing menthol on the tear film in healthy subjects and dry eye patients

Reiko Arita1,2,5, Naoyuki Morishige3,5, Ichiro Sakamoto4, Natsuko Imai4, Yuko Shimada4, Michihito Igaki4, Atsushi Suzuki4, Kouzo Itoh1, Kazuo Tsubota2

  • 1)Itoh Clinic, 626-11 Minami-Nakano, Minuma-ku, Saitama, Saitama 337-0042, Japan
  • 2)Department of Ophthalmology, Keio University, 35 Shinanomachi, Shinjyuku-ku, Tokyo 160-0016, Japan
  • 3)Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
  • 4)Personal Health Care Products Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-0044, Japan
  • 5)Lid and Meibomian Gland Working Group, Japan

Development of Definitive and Reliable Grading Scales for Meibomian Gland Dysfunction

Reiko Arita, Isumi Minoura, Naoyuki Morishige, Rika Shirakawa, Shima Fukuoka, Kei Asai, Tateki Goto, Takahiro Imanaka, Masatsugu Nakamura

<abstract>

Tear Interferometric Patterns Reflect Clinical Tear Dynamics in Dry Eye Patients
Reiko Arita1,2, Naoyuki Morishige2,3, Tatsuya Fujii2,4, Shima Fukuoka2,5, Jae Lim Chung6, Kyoung Yul Seo7, and Kouzo Itoh1

  • 1)Itoh Clinic, Saitama, Japan
  • 2)Lid and Meibomian Gland Working Group, Japan
  • 3)Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
  • 4)Kowa Pharmaceutical Co. Ltd., Nagoya, Japan
  • 5)Omiya Hamada Eye Clinic, Saitama, Japan
  • 6)Kim’s Eye Hospital, Konyang University College of Medicine, Seoul, South Korea
  • 7)Department of Ophthalmology, Yonsei University College of Medicine, Seoul, South Korea
<abstract>

Morphological changes in the meibomian glands of patients with phlyctenular keratitis: A Multicenter Cross-sectional Study
Takashi Suzuki, M.D.1,2, Naoyuki Morishige, M.D.1,3, Reiko Arita, M.D.1,4,5, Shizuka Koh, M.D.1,6, Tohru Sakimoto,M.D.1,7, Rika Shirakawa, M.D.1,4, Kazunori Miyata, M.D.8, Yuichi Ohashi, M.D.2

  • 1)LIME (Lid and Meibomian gland) working group
  • 2)Department of Ophthalmology, Ehime University, Graduate School of Medicine, Toon, Japan
  • 3)Department of Ophthalmology, Yamaguchi University, Graduate School of Medicine, Ube, Japan
  • 4)Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan
  • 5)Department of Ophthalmology, Itoh Clinic, Saitama, Japan
  • 6)Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • 7)Department of Visual Sciences, Division of Ophthalmology, Nihon University School of Medicine, Tokyo, Japan
  • 8)Miyata Eye Hospital, Miyakonojo, Japan
<abstract>

Effects of eyelid warming devices on tear film parameters in normal subjects and patients with meibomian gland dysfunction
Short title: Evaluation of eyelid warming devices
Reiko Aritaa,b,c,d, Naoyuki Morishiged,e, Rika Shirakawab,d,
Yoichi Satof, and Shiro Amanog,h

  • a)Department of Ophthalmology, Itoh Clinic, 626-11 Minami-Nakano, Minuma, Saitama, Saitama 337-0042, Japan
  • b)Department of Ophthalmology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-8654, Japan
  • c)Department of Ophthalmology, Keio University, 35 Shinano-Machi, Shinjuku-Ku, Tokyo 160-8582, Japan
  • d)Lid and Meibomian Gland Working Group
  • e)Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
  • f)Yamaguchi University Hospital, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
  • g)Inoue Eye Hospital, 4-3 Kanda Surugadai, Chiyoda-Ku, Tokyo 101-0062, Japan
  • h)Miyata Eye Hospital, 6-3 Kurahara-Chou, Miyakonojo, Miyazaki 885-0051, Japan

Increased tear fluid production as a compensatory response to meibomian
gland loss: a multicenter cross-sectional study
Reiko Arita1,2,3,4 MD, PhD, Naoyuki Morishige1,5 MD, PhD,
Shizuka Koh1,6 MD, PhD, Rika Shirakawa1,3 MD,
Motoko Kawashima1,4 MD, PhD, Tohru Sakimoto1,7 MD, PhD,
Takashi Suzuki1,8 MD, PhD, and Kazuo Tsubota4 MD, PhD

  • 1)Lid and Meibomian Gland Working Group, Japan
  • 2)Department of Ophthalmology, Itoh Clinic, Saitama, Japan
  • 3)Department of Ophthalmology, The University of Tokyo, Tokyo, Japan
  • 4)Department of Ophthalmology, Keio University School of Medicine, Tokyo,
    Japan
  • 5)Department of Ophthalmology, Yamaguchi University Graduate School of
    Medicine, Yamaguchi, Japan
  • 6)Department of Ophthalmology, Osaka University Graduate School of Medicine,
    Osaka, Japan
  • 7)Department of Ophthalmology, Nihon University School of Medicine, Tokyo,
    Japan
  • 8)Department of Ophthalmology, Ehime University Graduate School of Medicine,
    Ehime, Japan
<abstract>

Ophthalmology in press

LIMEメンバーのマイボーム腺関連疾患の論文

Meibum Color and Free Fatty Acid Composition in Patients with Meibomian Gland Dysfunction
Reiko Arita,1,2 Naoto Mori,3 Rika Shirakawa,1 Kei Asai,3 Takahiro Imanaka,3 Yasufumi Fukano,3 Masatsugu Nakamura,3 Shiro Amano4

Running Head: Meibum color and Meibum composition in MGD

  • 1)Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
  • 2)Department of Ophthalmology, Itoh Clinic, 626-11 Minaminakano, Minuma-ku, Saitama city, Saitama 337-0042, Japan
  • 3)Research and Development Division, Santen Pharmaceutical Co. Ltd., 4-20 Ofuka-cho, Kita-ku, Osaka 530-8552, Japan
  • 4)Inouye Eye Hospital, 4-3 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

Correspondence: Reiko Arita, MD, PhD

Department of Ophthalmology, Itoh Clinic, 626-11 Minaminakano, Minuma-ku,
Saitama city, Saitama 337-0042, Japan

IOVS in press

  • Koh S, Ikeda C, Fujimoto H, Oie Y, Soma T, Maeda N, Nishida K. Regional
    Differences in Tear Film Stability and Meibomian Glands in Patients With
    Aqueous-Deficient Dry Eye. Eye Contact Lens. 2015 Sep 16. [Epub ahead of print]

マイボグラフィーを用いたドライアイ関連疾患以外の応用編

  • Nemoto Y, Arita R, Mizota A, Sasajima Y.
    Differentiation between chalazion and sebaceous carcinoma by noninvasive meibography
    Clinical Ophthalmology September 2014 Volume 2014:8 Pages 1869-1875
  • Sakimoto T: Granular corneal dystrophy type 2 is associated with morphological abnormalities of meibomian glands. Br J Ophthalmol: in press.
  • Morishige N, Yamada N, Morita Y, Sonoda KH. Peters’ anomaly imaged with an infrared anterior segment camera.
    Clin Experiment Ophthalmol. 2014 May;42(4):391-2.
  • Koh S, Maeda N, Nishida K. Visualization of the meibomian glands by means of noncontact mobile-type meibography (Meibopen) in a 16-year-old girl with unilateral marginal staphylococcal keratitis.
    J AAPOS. 2014 Feb;18(1):99-101.

雑誌掲載

日本眼科学会雑誌118巻 第6号523

日本で市販されている5種類の温罨法の眼表面への効果の比較検討
有田玲子1,4、森重直行4,5、白川理香2,4、佐藤洋一5、天野史郎2

  • 1)伊藤医院
  • 2)東京大
  • 3)慶應大
  • 4)LIME研究会
  • 5)山口大